Vascular Remodelling and Mesenchymal Transition in Systemic Sclerosis

• Main Authors: Pier Andrea Nicolosi (Author), Enrico Tombetti (Author), Norma Maugeri (Author), Patrizia Rovere-Querini (Author), Silvia Brunelli (Author), Angelo A. Manfredi (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fibrosis of the skin and of internal organs, autoimmunity, and vascular inflammation are hallmarks of Systemic Sclerosis (SSc). The injury and activation of endothelial cells, with hyperplasia of the intima and eventual obliteration of the vascular lumen, are early features of SSc. Reduced capillary...