Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling

• Main Authors: Hong-Jing Zhou (Author), Hui Li (Author), Meng-Qi Shi (Author), Xiao-Na Mao (Author), Dong-Ling Liu (Author), Yi-Ran Chang (Author), Yu-Miao Gan (Author), Xi Kuang (Author), Jun-Rong Du (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aging is the greatest independent risk factor for the occurrence of stroke and poor outcomes, at least partially through progressive increases in oxidative stress and inflammation with advanced age. Klotho is an antiaging gene, the expression of which declines with age. Klotho may protect against ne...