Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles

• Main Authors: Mae M. Lewis (Author), Melissa R. Soto (Author), Esther Y. Maier (Author), Steven D. Wulfe (Author), Sandy Bakheet (Author), Hannah Obregon (Author), Debadyuti Ghosh (Author)
• Format: Book
• Published: Wiley, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Although mRNA lipid nanoparticles (LNPs) are highly effective as vaccines, their efficacy for pulmonary delivery has not yet fully been established. A major barrier to this therapeutic goal is their instability during aerosolization for local delivery. This imparts a shear force that degrad...