Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles

• Asıl Yazarlar: Mae M. Lewis (Yazar), Melissa R. Soto (Yazar), Esther Y. Maier (Yazar), Steven D. Wulfe (Yazar), Sandy Bakheet (Yazar), Hannah Obregon (Yazar), Debadyuti Ghosh (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2023-11-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Although mRNA lipid nanoparticles (LNPs) are highly effective as vaccines, their efficacy for pulmonary delivery has not yet fully been established. A major barrier to this therapeutic goal is their instability during aerosolization for local delivery. This imparts a shear force that degrad...