Global Autorecognition and Activation of Complement by Mannan-Binding Lectin in a Mouse Model of Type 1 Diabetes

• Principais autores: Esben Axelgaard (Autor), Jakob Appel Østergaard (Autor), Saranda Haxha (Autor), Steffen Thiel (Autor), Troels Krarup Hansen (Autor)
• Formato: Livro
• Publicado em: Hindawi Limited, 2017-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Increasing evidence links mannan-binding lectin (MBL) to late vascular complications of diabetes. MBL is a complement-activating pattern recognition molecule of the innate immune system that can mediate an inflammation response through activation of the lectin pathway. In two recent animal studies,...