Integrative genomic analyses of APOBEC-mutational signature, expression and germline deletion of APOBEC3 genes, and immunogenicity in multiple cancer types

• Main Authors: Zhishan Chen (Author), Wanqing Wen (Author), Jiandong Bao (Author), Krystle L. Kuhs (Author), Qiuyin Cai (Author), Jirong Long (Author), Xiao-ou Shu (Author), Wei Zheng (Author), Xingyi Guo (Author)
• Format: Book
• Published: BMC, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Although APOBEC-mutational signature is found in tumor tissues of multiple cancers, how a common germline APOBEC3A/B deletion affects the mutational signature remains unclear. Methods Using data from 10 cancer types generated as part of TCGA, we performed integrative genomic and...