A Kidney-Targeted Nanoparticle to Augment Renal Lymphatic Density Decreases Blood Pressure in Hypertensive Mice

• Main Authors: Bethany L. Goodlett (Author), Chang Sun Kang (Author), Eunsoo Yoo (Author), Shobana Navaneethabalakrishnan (Author), Dakshnapriya Balasubbramanian (Author), Sydney E. Love (Author), Braden M. Sims (Author), Daniela L. Avilez (Author), Winter Tate (Author), Delilah R. Chavez (Author), Gaurav Baranwal (Author), Mary B. Nabity (Author), Joseph M. Rutkowski (Author), Dongin Kim (Author), Brett M. Mitchell (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic interstitial inflammation and renal infiltration of activated immune cells play an integral role in hypertension. Lymphatics regulate inflammation through clearance of immune cells and excess interstitial fluid. Previously, we demonstrated increasing renal lymphangiogenesis prevents hyperten...