Inhibitors of Farnesyl Diphosphate Synthase and Squalene Synthase: Potential Source for Anti-<i>Trypanosomatidae</i> Drug Discovery

• Main Authors: Boniface Pone Kamdem (Author), Fabrice Fekam Boyom (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2023-08-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Trypanosomatids are mainly responsible for leishmaniasis, sleeping sickness, and Chagas disease, which are the most challenging among the neglected tropical diseases due to the problem of drug resistance. Although problems of target deconvolution and polypharmacology are encountered, a target-based...