Synthesis, anticancer and apoptosis-inducing activities of quinazoline-isatin conjugates: epidermal growth factor receptor-tyrosine kinase assay and molecular docking studies

• Main Authors: Adel S. El-Azab (Author), Abdullah Al-Dhfyan (Author), Alaa A.-M (Author), Laila A. Abou-Zeid (Author), Hamad M. Alkahtani (Author), Abdulrahman M. Al-Obaid (Author), Manal A. Al-Gendy (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new series of quinazolinone compounds 16-34 incorporating isatin moieties was synthesized. The antitumor efficacy of the compounds against MDA-MB-231, a breast cancer cell line, and LOVO, a colon cancer cell line, was assessed. Compounds 20, 21, 22, 23, 25, 27, 28, 29, 30, 31, 32, 33, and 34 displ...