Muscle atrophy in patients wirh ckd results from fgf23/klotho-mediated supression of insulin/igf-i signaling

• Main Authors: Shinsuke Kido (Author), Yui Hashimoto (Author), Hiroko Segawa (Author), Sawako Tatsumi (Author), Ken-ichi Miyamoto (Author)
• Format: Book
• Published: The Korean Society of Nephrology, 2012-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Muscle atrophy is a significant consequence of chronic kidney disease (CKD) that increases a patient's risk of mortality and decrease their quality of life. In CKD patients, the circulation levels of FGF23 are significantly increased, but the exact pathological significance of the increase and...