NanoSIMS Imaging Reveals the Impact of Ligand-ASO Conjugate Stability on ASO Subcellular Distribution

• Main Authors: Emma Kay (Author), Rouven Stulz (Author), Cécile Becquart (Author), Jelena Lovric (Author), Carolina Tängemo (Author), Aurélien Thomen (Author), Dženita Baždarević (Author), Neda Najafinobar (Author), Anders Dahlén (Author), Anna Pielach (Author), Julia Fernandez-Rodriguez (Author), Roger Strömberg (Author), Carina Ämmälä (Author), Shalini Andersson (Author), Michael Kurczy (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The delivery of antisense oligonucleotides (ASOs) to specific cell types via targeted endocytosis is challenging due to the low cell surface expression of target receptors and inefficient escape of ASOs from the endosomal pathway. Conjugating ASOs to glucagon-like peptide 1 (GLP1) leads to efficient...