NanoSIMS Imaging Reveals the Impact of Ligand-ASO Conjugate Stability on ASO Subcellular Distribution

• Автори: Emma Kay (Автор), Rouven Stulz (Автор), Cécile Becquart (Автор), Jelena Lovric (Автор), Carolina Tängemo (Автор), Aurélien Thomen (Автор), Dženita Baždarević (Автор), Neda Najafinobar (Автор), Anders Dahlén (Автор), Anna Pielach (Автор), Julia Fernandez-Rodriguez (Автор), Roger Strömberg (Автор), Carina Ämmälä (Автор), Shalini Andersson (Автор), Michael Kurczy (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2022-02-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The delivery of antisense oligonucleotides (ASOs) to specific cell types via targeted endocytosis is challenging due to the low cell surface expression of target receptors and inefficient escape of ASOs from the endosomal pathway. Conjugating ASOs to glucagon-like peptide 1 (GLP1) leads to efficient...