NanoSIMS Imaging Reveals the Impact of Ligand-ASO Conjugate Stability on ASO Subcellular Distribution

• मुख्य लेखकों: Emma Kay (लेखक), Rouven Stulz (लेखक), Cécile Becquart (लेखक), Jelena Lovric (लेखक), Carolina Tängemo (लेखक), Aurélien Thomen (लेखक), Dženita Baždarević (लेखक), Neda Najafinobar (लेखक), Anders Dahlén (लेखक), Anna Pielach (लेखक), Julia Fernandez-Rodriguez (लेखक), Roger Strömberg (लेखक), Carina Ämmälä (लेखक), Shalini Andersson (लेखक), Michael Kurczy (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2022-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The delivery of antisense oligonucleotides (ASOs) to specific cell types via targeted endocytosis is challenging due to the low cell surface expression of target receptors and inefficient escape of ASOs from the endosomal pathway. Conjugating ASOs to glucagon-like peptide 1 (GLP1) leads to efficient...