Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids
The role of G-quadruplexes in human cancers is increasingly well-defined. Accordingly, G-quadruplexes can be suitable drug targets and many small molecules have been identified to date as G-quadruplex binders, some using computer-based design methods and co-crystal structures. The role of bound wate...
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MDPI AG,
2021-12-01T00:00:00Z.
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