Berberine Promotes OATP1B1 Expression and Rosuvastatin Uptake by Inducing Nuclear Translocation of FXR and LXRα

• Main Authors: Mingyi Liu (Author), Dandan Zhu (Author), Jinhua Wen (Author), Wei Ding (Author), Shibo Huang (Author), Chunhua Xia (Author), Hong Zhang (Author), Yuqing Xiong (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Fag: article
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Berberine, a quinoline alkaloid, can be used in combination with statins to enhance hypolipidemic effects and reduce the dose and side effects of statins. The hypolipidemic effects of statins in the liver are mainly regulated by organic anion transporting polypeptides (OATPs), and the expression of...