In Vitro and In Silico Analyses of Nicotine Release from a Gelisphere-Loaded Compressed Polymeric Matrix for Potential Parkinson's Disease Interventions

• Main Authors: Pradeep Kumar (Author), Yahya E. Choonara (Author), Lisa C. du Toit (Author), Neha Singh (Author), Viness Pillay (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2018-11-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

This study aimed to develop a prolonged-release device for the potential site-specific delivery of a neuroprotective agent (nicotine). The device was formulated as a novel reinforced crosslinked composite polymeric system with the potential for intrastriatal implantation in Parkinson’s dis...