A Dynamic Quantitative Systems Pharmacology Model of Inflammatory Bowel Disease: Part 1 - Model Framework

• Autori principali: Katharine V. Rogers (Autore), Steven W. Martin (Autore), Indranil Bhattacharya (Autore), Ravi Shankar Prasad Singh (Autore), Satyaprakash Nayak (Autore)
• Natura: Libro
• Pubblicazione: Wiley, 2021-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

A mechanistic, multistate, mathematical model of inflammatory bowel disease (IBD) was developed by including key biological mechanisms in blood and gut, including cell differentiation, cytokine production, and clinical biomarkers. The model structure is consistent between healthy volunteers and IBD...