Model-Informed Drug Development of New Cefoperazone Sodium and Sulbactam Sodium Combination (3:1): Pharmacokinetic/Pharmacodynamic Analysis and Antibacterial Efficacy Against Enterobacteriaceae

• Autori principali: Xi-Wei Ji (Autore), Xiao Zhu (Autore), Yun Li (Autore), Feng Xue (Autore), Isabelle Hui San Kuan (Autore), Qing-Feng He (Autore), Xiang-Rui Meng (Autore), Xiao-Qiang Xiang (Autore), Yi-Min Cui (Autore), Bo Zheng (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Objective: Cefoperazone/sulbactam is a commonly used antibiotic combination against the extended-spectrum beta-lactamases (ESBLs)-producing bacteria. The objective of this study was to evaluate the efficacy of a new cefoperazone/sulbactam combination (3:1) for Enterobacteriaceae infection via model-...