Central monitoring of depression and anxiety symptoms reduces placebo responses in depression clinical trials: A post hoc exploratory analysis of data from the phase III CCT‐004 trial of vortioxetine

• Main Authors: Yoshinori Watanabe (Author), Akira Nishimura (Author), Toshiaki Kikuchi (Author), Norifusa Sawada (Author), Manami Imazaki (Author), Isao Inada (Author), Koichiro Watanabe (Author)
• Format: Book
• Published: Wiley, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Aim Clinical trials of antidepressants often fail to demonstrate their efficacy versus placebo, suggesting that patient selection based on physician ratings of depression may contribute to a high placebo response. Methods In the CCT‐004 trial of vortioxetine, central monitoring was employed...