Targeting Echinococcus multilocularis stem cells by inhibition of the Polo-like kinase EmPlk1.

• Main Authors: Andreas Schubert (Author), Uriel Koziol (Author), Katia Cailliau (Author), Mathieu Vanderstraete (Author), Colette Dissous (Author), Klaus Brehm (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alveolar echinococcosis (AE) is a life-threatening disease caused by larvae of the fox-tapeworm Echinococcus multilocularis. Crucial to AE pathology is continuous infiltrative growth of the parasite's metacestode stage, which is driven by a population of somatic stem cells, called germinative c...