GYF-21, an Epoxide 2-(2-Phenethyl)-Chromone Derivative, Suppresses Innate and Adaptive Immunity via Inhibiting STAT1/3 and NF-κB Signaling Pathways
Multiple sclerosis is a chronic inflammatory autoimmune disease of the central nervous system characterized by demyelinating plaques and axonal loss. Inhibition on over activation of innate and adaptive immunity provides a rationale strategy for treatment of multiple sclerosis. In the present study,...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Book |
| Published: |
Frontiers Media S.A.,
2017-05-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_0a61a2c39b1649f1bae9108a8c31e9c5 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Ran Guo |e author |
| 700 | 1 | 0 | |a Yun-Fang Zhao |e author |
| 700 | 1 | 0 | |a Jun Li |e author |
| 700 | 1 | 0 | |a Yu-Fan Gu |e author |
| 700 | 1 | 0 | |a Hui-Xia Huo |e author |
| 700 | 1 | 0 | |a Shan-Shan Li |e author |
| 700 | 1 | 0 | |a Yue-Lin Song |e author |
| 700 | 1 | 0 | |a Zhi-Xiang Zhu |e author |
| 700 | 1 | 0 | |a Peng-Fei Tu |e author |
| 245 | 0 | 0 | |a GYF-21, an Epoxide 2-(2-Phenethyl)-Chromone Derivative, Suppresses Innate and Adaptive Immunity via Inhibiting STAT1/3 and NF-κB Signaling Pathways |
| 260 | |b Frontiers Media S.A., |c 2017-05-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2017.00281 | ||
| 520 | |a Multiple sclerosis is a chronic inflammatory autoimmune disease of the central nervous system characterized by demyelinating plaques and axonal loss. Inhibition on over activation of innate and adaptive immunity provides a rationale strategy for treatment of multiple sclerosis. In the present study, we investigated the inhibitory effects of GYF-21, an epoxide 2-(2-phenethyl)-chromone derivative isolated from Chinese agarwood, on innate and adaptive immunity for revealing its potential to treat multiple sclerosis. The results showed that GYF-21 markedly inhibited the activation of microglia, and dendritic cells as well as neutrophils, all of which play important roles in innate immunity. Furthermore, GYF-21 significantly suppressed adaptive immunity via inhibiting the differentiation of naive CD4+ T cells into T helper 1 (Th1) and T helper 17 (Th17) cells, and suppressing the activation, proliferation, and IFN-γ secretion of CD8+ T cells. The mechanism study showed that GYF-21 evidently inhibited the activation of STAT1/3 and NF-κB signaling pathways in microglia. In conclusion, we demonstrated that GYF-21 can significantly inhibit innate and adaptive immunity via suppressing STAT1/3 and NF-κB signaling pathways, and has potential to be developed into therapeutic drug for multiple sclerosis. | ||
| 546 | |a EN | ||
| 690 | |a multiple sclerosis | ||
| 690 | |a epoxide 2-(2-phenethyl)-chromone | ||
| 690 | |a innate immunity | ||
| 690 | |a adaptive immunity | ||
| 690 | |a STAT1/3 signaling pathway | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 8 (2017) | |
| 787 | 0 | |n http://journal.frontiersin.org/article/10.3389/fphar.2017.00281/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/0a61a2c39b1649f1bae9108a8c31e9c5 |z Connect to this object online. |