A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity.

• Hauptverfasser: Elizabeth R Sharlow (Verfasst von), Todd A Lyda (Verfasst von), Heidi C Dodson (Verfasst von), Gabriela Mustata (Verfasst von), Meredith T Morris (Verfasst von), Stephanie S Leimgruber (Verfasst von), Kuo-Hsiung Lee (Verfasst von), Yoshiki Kashiwada (Verfasst von), David Close (Verfasst von), John S Lazo (Verfasst von), James C Morris (Verfasst von)
• Format: Buch
• Veröffentlicht: Public Library of Science (PLoS), 2010-04-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

The parasitic protozoan Trypanosoma brucei utilizes glycolysis exclusively for ATP production during infection of the mammalian host. The first step in this metabolic pathway is mediated by hexokinase (TbHK), an enzyme essential to the parasite that transfers the gamma-phospho of ATP to a hexose. He...