Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats

• Main Authors: Nobuaki Egashira (Author), Yu Goto (Author), Ryota Takahashi (Author), Hikari Iba (Author), Shota Yamamoto (Author), Takuya Watanabe (Author), Kaori Kubota (Author), Takehiro Kawashiri (Author), Chise Taniguchi (Author), Shutaro Katsurabayashi (Author), Katsunori Iwasaki (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxaliplatin is a key drug used in the management of solid tumors, such as colorectal cancer; however, it causes peripheral neuropathy. In this study, we investigated the effect of ibudilast, a phosphodiesterase inhibitor, on oxaliplatin-induced mechanical allodynia and histological changes in rats....