Correlation network analysis shows divergent effects of a long-term, high-fat diet and exercise on early stage osteoarthritis phenotypes in mice

• প্রধান লেখক: Timothy M. Griffin (লেখক), Albert Batushansky (লেখক), Joanna Hudson (লেখক), Erika Barboza Prado Lopes (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2020-03-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Background: Obesity increases knee osteoarthritis (OA) risk through metabolic, inflammatory, and biomechanical factors, but how these systemic and local mediators interact to drive OA pathology is not well understood. We tested the effect of voluntary running exercise after chronic diet-induced obes...