Quantitative systems pharmacology modeling provides insight into inter‐mouse variability of Anti‐CTLA4 response

• 主要な著者: Wenlian Qiao (著者), Lin Lin (著者), Carissa Young (著者), Jatin Narula (著者), Fei Hua (著者), Andrew Matteson (著者), Andrea Hooper (著者), Lore Gruenbaum (著者), Alison Betts (著者)
• フォーマット: 図書
• 出版事項: Wiley, 2022-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract Clinical responses of immuno‐oncology therapies are highly variable among patients. Similar response variability has been observed in syngeneic mouse models. Understanding of the variability in the mouse models may shed light on patient variability. Using a murine anti‐CTLA4 antibody as a c...