Quantitative systems pharmacology modeling provides insight into inter‐mouse variability of Anti‐CTLA4 response

• Main Authors: Wenlian Qiao (Author), Lin Lin (Author), Carissa Young (Author), Jatin Narula (Author), Fei Hua (Author), Andrew Matteson (Author), Andrea Hooper (Author), Lore Gruenbaum (Author), Alison Betts (Author)
• Format: Book
• Published: Wiley, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Clinical responses of immuno‐oncology therapies are highly variable among patients. Similar response variability has been observed in syngeneic mouse models. Understanding of the variability in the mouse models may shed light on patient variability. Using a murine anti‐CTLA4 antibody as a c...