Exploring the Complexity of Processing-Induced Dehydration during Hot Melt Extrusion Using In-Line Raman Spectroscopy

• Main Authors: Lærke Arnfast (Author), Jeroen van Renterghem (Author), Johanna Aho (Author), Johan Bøtker (Author), Dhara Raijada (Author), Stefania Baldursdóttir (Author), Thomas De Beer (Author), Jukka Rantanen (Author)
• Format: Book
• Published: MDPI AG, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The specific aim in this study was to understand the effect of critical process parameters on the solid form composition of model drug compounds during hot melt extrusion using in-line Raman spectroscopy combined with Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) modeling for sem...