Implementation and Cross-Validation of a Pharmacokinetic Model for Precision Dosing of Busulfan in Hematopoietic Stem Cell Transplanted Children

• Auteurs principaux: Sylvain Goutelle (Auteur), Yann Thoma (Auteur), Roxane Buffet (Auteur), Michael Philippe (Auteur), Thierry Buclin (Auteur), Monia Guidi (Auteur), Chantal Csajka (Auteur)
• Format: Livre
• Publié: MDPI AG, 2022-10-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Busulfan, a drug used in conditioning prior to hematopoietic stem cell transplantation (HSCT) in children, has a narrow therapeutic margin. The model-informed precision dosing (MIPD) of busulfan is desirable, but there is a lack of validated tools. The objective of this study was to implement and cr...