Synthesis, Biophysical Properties, and Antitumor Activity of Antisense Oligonucleotides Conjugated with Anisamide
Antisense oligonucleotides (ASONs) have proven potential for the treatment of various diseases. However, their limited bioavailability restricts their clinical application. New structures with improved enzyme resistance stability and efficient drug delivery are needed. In this work, we propose a nov...
Saved in:
Main Authors: | Zhe Zhang (Author), Zuyi Chen (Author), Cheng Li (Author), Zhenyu Xiao (Author), Yuan Luo (Author), Xiaochen Pan (Author), Liang Xu (Author), Xuesong Feng (Author) |
---|---|
Format: | Book |
Published: |
MDPI AG,
2023-06-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol
by: Tomoko Nishina, et al.
Published: (2015) -
Tritium labeling of antisense oligonucleotides via different conjugation agents
by: Martin R. Edelmann, et al.
Published: (2021) -
Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys
by: Colby S Shemesh, et al.
Published: (2016) -
GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells
by: Sabine Sewing, et al.
Published: (2019) -
Antibody-Antisense Oligonucleotide Conjugate Downregulates a Key Gene in Glioblastoma Stem Cells
by: Amy E. Arnold, et al.
Published: (2018)