Silkworm recombinant bovine zona pellucida protein 4 (bZP4) as a potential female immunocontraceptive antigen; impaired sperm-oocyte interaction and ovarian dysfunction

• Main Authors: Ken-ichiro TATEMATSU (Author), Mitsumi IKEDA (Author), Yoshihiro WAKABAYASHI (Author), Takashi YAMAMURA (Author), Kazuhiro KIKUCHI (Author), Junko NOGUCHI (Author), Hideki SEZUTSU (Author)
• Format: Book
• Published: The Society for Reproduction and Development, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Porcine zona pellucida proteins (ZPs) have been utilized as female immunocontraceptive antigens. The purpose of this study was to explore the potential use of silkworm recombinant bovine ZP4 as an alternative. When the protein was injected with monophosphoryl lipid A (MPL) - an immuno-stimulative ag...