Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering

• Main Authors: Nicolas O. Jørgensen (Author), Rasmus Kjøbsted (Author), Magnus R. Larsen (Author), Jesper B. Birk (Author), Nicoline R. Andersen (Author), Bina Albuquerque (Author), Peter Schjerling (Author), Russell Miller (Author), David Carling (Author), Christian K. Pehmøller (Author), Jørgen F.P. Wojtaszewski (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Skeletal muscle is an attractive target for blood glucose-lowering pharmacological interventions. Oral dosing of small molecule direct pan-activators of AMPK that bind to the allosteric drug and metabolite (ADaM) site, lowers blood glucose through effects in skeletal muscle. The molecular...