The wasp venom antimicrobial peptide polybia‐CP and its synthetic derivatives display antiplasmodial and anticancer properties

• Main Authors: Marcelo D. T. Torres (Author), Adriana F. Silva (Author), Gislaine P. Andrade (Author), Cibele N. Pedron (Author), Giselle Cerchiaro (Author), Anderson O. Ribeiro (Author), Vani X. Oliveira Jr (Author), Cesar de laFuente‐Nunez (Author)
• Format: Book
• Published: Wiley, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The wasp venom‐derived antimicrobial peptide polybia‐CP has been previously shown to exhibit potent antimicrobial activity, but it is also highly toxic. Previously, using a physicochemical‐guided peptide design strategy, we reversed its toxicity while preserving and even enhancing its antib...