The effect of current Schistosoma mansoni infection on the immunogenicity of a candidate TB vaccine, MVA85A, in BCG-vaccinated adolescents: An open-label trial.

• Main Authors: Anne Wajja (Author), Dennison Kizito (Author), Beatrice Nassanga (Author), Angela Nalwoga (Author), Joyce Kabagenyi (Author), Simon Kimuda (Author), Ronald Galiwango (Author), Gertrude Mutonyi (Author), Samantha Vermaak (Author), Iman Satti (Author), Jaco Verweij (Author), Edridah Tukahebwa (Author), Stephen Cose (Author), Jonathan Levin (Author), Pontiano Kaleebu (Author), Alison M Elliott (Author), Helen McShane (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Helminth infection may affect vaccine immunogenicity and efficacy. Adolescents, a target population for tuberculosis booster vaccines, often have a high helminth burden. We investigated effects of Schistosoma mansoni (Sm) on the immunogenicity and safety of MVA85A, a model candidate tuberculosis vac...