In-Silico Characterization and in-Vivo Validation of Albiziasaponin-A, Iso-Orientin, and Salvadorin Using a Rat Model of Alzheimer's Disease

• Main Authors: Mahmood Rasool (Author), Arif Malik (Author), Sulayman Waquar (Author), Qura Tul-Ain (Author), Tassadaq H. Jafar (Author), Rabia Rasool (Author), Aasia Kalsoom (Author), Muhammad A. Ghafoor (Author), Sheikh A. Sehgal (Author), Kalamegam Gauthaman (Author), Muhammad I. Naseer (Author), Mohammed H. Al-Qahtani (Author), Peter N. Pushparaj (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia, excessive acetylcholinesterase (AChE) activity, formation of neurotoxic amyloid plaque, and tau protein aggregation. Based on literature survey, we have shortlisted three important target proteins (AChE, COX2, a...