Effect of a Selective Inhibitor of Secretory Phospholipase A2, S-5920/LY315920Na, on Experimental Acute Pancreatitis in Rats

Effect of a Selective Inhibitor of Secretory Phospholipase A2, S-5920/LY315920Na, on Experimental Acute Pancreatitis in Rats

We investigated the efficacy of a potent inhibitor of secretory phospholipase A2 (sPLA2), S-5920/LY315920Na, in an experimental model of acute pancreatitis in rats. Combined intraductal injection of sodium taurocholate (5 mg/rat) and porcine pancreatic sPLA2-IB (300 μg/rat) caused severe hemorrhagic...

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Main Authors: Yasuhiko Tomita (Author), Kenji Kuwabara (Author), Shingo Furue (Author), Kazushige Tanaka (Author), Katsutoshi Yamada (Author), Masahiko Ueno (Author), Takashi Ono (Author), Toshiyuki Maruyama (Author), Tetsuo Ajiki (Author), Hirohiko Onoyama (Author), Masahiro Yamamoto (Author), Yozo Hori (Author)
Format: Book
Published: Elsevier, 2004-01-01T00:00:00Z.
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