Tryptophan 2,3-dioxygenase 2 controls M2 macrophages polarization to promote esophageal squamous cell carcinoma progression via AKT/GSK3β/IL-8 signaling pathway

• Автори: Yumiao Zhao (Автор), Jiaxin Sun (Автор), Yin Li (Автор), Xiuman Zhou (Автор), Wenjie Zhai (Автор), Yahong Wu (Автор), Guanyu Chen (Автор), Shanshan Gou (Автор), Xinghua Sui (Автор), Wenshan Zhao (Автор), Lu Qiu (Автор), Yongjie Yao (Автор), Yixuan Sun (Автор), Chunxia Chen (Автор), Yuanming Qi (Автор), Yanfeng Gao (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2021-09-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Tryptophan 2,3-dioxygnease 2 (TDO2) is specific for metabolizing tryptophan to kynurenine (KYN), which plays a critical role in mediating immune escape of cancer. Although accumulating evidence demonstrates that TDO2 overexpression is implicated in the development and progression of multiple cancers...