Tryptophan 2,3-dioxygenase 2 controls M2 macrophages polarization to promote esophageal squamous cell carcinoma progression via AKT/GSK3β/IL-8 signaling pathway

• Main Authors: Yumiao Zhao (Author), Jiaxin Sun (Author), Yin Li (Author), Xiuman Zhou (Author), Wenjie Zhai (Author), Yahong Wu (Author), Guanyu Chen (Author), Shanshan Gou (Author), Xinghua Sui (Author), Wenshan Zhao (Author), Lu Qiu (Author), Yongjie Yao (Author), Yixuan Sun (Author), Chunxia Chen (Author), Yuanming Qi (Author), Yanfeng Gao (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tryptophan 2,3-dioxygnease 2 (TDO2) is specific for metabolizing tryptophan to kynurenine (KYN), which plays a critical role in mediating immune escape of cancer. Although accumulating evidence demonstrates that TDO2 overexpression is implicated in the development and progression of multiple cancers...