Production of nanostructured molecular liquids by supercritical CO2 processing

• Main Authors: Sudhir Kumar Sharma (Author), Abiy D. Woldetsadik (Author), Thomas Blanton (Author), Matthew J. O'Connor (Author), Mazin Magzoub (Author), Ramesh Jagannathan (Author)
• Format: Book
• Published: Elsevier, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Stable molecular clusters of ibuprofen and naproxen were prepared in dry ice, by supersonic jet expansion of their supercritical CO2 drug formulations into a liquid nitrogen cooled collection vessel, with up to 80% yield. Mixing the "dry ice" in water, resulted in the solubilization of the...