A Validated Chiral LC-MS/MS Method for the Enantioselective Determination of (S)-(+)- and (R)-(-)-Ibuprofen in Dog Plasma: Its Application to a Pharmacokinetic Study

• Main Authors: Sanghee Choi (Author), Wang-Seob Shim (Author), Jiyoung Yoon (Author), Doowon Choi (Author), Jinseong Lee (Author), Soo-Heui Paik (Author), Eun-Kyoung Chung (Author), Kyung-Tae Lee (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of this study was to develop a method for simultaneously separating ibuprofen enantiomers using electrospray ionization (ESI) liquid chromatography with tandem mass spectrometry (LC-MS/MS). LC-MS/MS was operated with negative ionization and multiple reaction monitoring modes; transitions...