A Validated Chiral LC-MS/MS Method for the Enantioselective Determination of (S)-(+)- and (R)-(-)-Ibuprofen in Dog Plasma: Its Application to a Pharmacokinetic Study

• Principais autores: Sanghee Choi (Autor), Wang-Seob Shim (Autor), Jiyoung Yoon (Autor), Doowon Choi (Autor), Jinseong Lee (Autor), Soo-Heui Paik (Autor), Eun-Kyoung Chung (Autor), Kyung-Tae Lee (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2023-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The purpose of this study was to develop a method for simultaneously separating ibuprofen enantiomers using electrospray ionization (ESI) liquid chromatography with tandem mass spectrometry (LC-MS/MS). LC-MS/MS was operated with negative ionization and multiple reaction monitoring modes; transitions...