Gut-Sourced Vasoactive Intestinal Polypeptide Induced by the Activation of α7 Nicotinic Acetylcholine Receptor Substantially Contributes to the Anti-inflammatory Effect of Sinomenine in Collagen-Induced Arthritis

Sinomenine has long been used for the treatment of rheumatoid arthritis in China. However, its anti-inflammatory mechanism is still debatable because the in vitro minimal effective concentration (≥250 μM) is hardly reached in either synovium or serum after oral administration at a therapeutic dose....

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Main Authors: MengFan Yue (Author), XinYu Zhang (Author), YanNong Dou (Author), ZhiFeng Wei (Author), Yu Tao (Author), YuFeng Xia (Author), Yue Dai (Author)
Format: Book
Published: Frontiers Media S.A., 2018-06-01T00:00:00Z.
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3rd Floor Main Library

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