Gut-Sourced Vasoactive Intestinal Polypeptide Induced by the Activation of α7 Nicotinic Acetylcholine Receptor Substantially Contributes to the Anti-inflammatory Effect of Sinomenine in Collagen-Induced Arthritis

• Asıl Yazarlar: MengFan Yue (Yazar), XinYu Zhang (Yazar), YanNong Dou (Yazar), ZhiFeng Wei (Yazar), Yu Tao (Yazar), YuFeng Xia (Yazar), Yue Dai (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2018-06-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Sinomenine has long been used for the treatment of rheumatoid arthritis in China. However, its anti-inflammatory mechanism is still debatable because the in vitro minimal effective concentration (≥250 μM) is hardly reached in either synovium or serum after oral administration at a therapeutic dose....