Gut-Sourced Vasoactive Intestinal Polypeptide Induced by the Activation of α7 Nicotinic Acetylcholine Receptor Substantially Contributes to the Anti-inflammatory Effect of Sinomenine in Collagen-Induced Arthritis

• Hauptverfasser: MengFan Yue (Verfasst von), XinYu Zhang (Verfasst von), YanNong Dou (Verfasst von), ZhiFeng Wei (Verfasst von), Yu Tao (Verfasst von), YuFeng Xia (Verfasst von), Yue Dai (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2018-06-01T00:00:00Z.
• Schlagworte: article
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Sinomenine has long been used for the treatment of rheumatoid arthritis in China. However, its anti-inflammatory mechanism is still debatable because the in vitro minimal effective concentration (≥250 μM) is hardly reached in either synovium or serum after oral administration at a therapeutic dose....