Intravenous delivery of a liposomal formulation of voriconazole improves drug pharmacokinetics, tissue distribution, and enhances antifungal activity

• Main Authors: Danillo F. M. C. Veloso (Author), Naiara I. G. M. Benedetti (Author), Renato I. Ávila (Author), Thiago S. A. Bastos (Author), Thaísa C. Silva (Author), Maria R. R. Silva (Author), Aline C. Batista (Author), Marize C. Valadares (Author), Eliana M. Lima (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Voriconazole (VCZ), a triazole with a large spectrum of action is one of the most recommended antifungal agents as the first line therapy against several clinically important systemic fungal infections, including those by Candida albicans. This antifungal has moderate water solubility and exhibits a...