Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein

• Main Authors: Nigel Davies (Author), Daniel Hovdal (Author), Nicholas Edmunds (Author), Peter Nordberg (Author), Anders Dahlén (Author), Aleksandra Dabkowska (Author), Marianna Yanez Arteta (Author), Aurel Radulescu (Author), Tomas Kjellman (Author), Andreas Höijer (Author), Frank Seeliger (Author), Elin Holmedal (Author), Elisabeth Andihn (Author), Nils Bergenhem (Author), Ann-Sofie Sandinge (Author), Camilla Johansson (Author), Leif Hultin (Author), Marie Johansson (Author), Johnny Lindqvist (Author), Liselotte Björsson (Author), Yujia Jing (Author), Stefano Bartesaghi (Author), Lennart Lindfors (Author), Shalini Andersson (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lipid nanoparticles (LNPs) are the most clinically advanced delivery system for RNA-based drugs but have predominantly been investigated for intravenous and intramuscular administration. Subcutaneous administration opens the possibility of patient self-administration and hence long-term chronic trea...