Application of SHAP values for inferring the optimal functional form of covariates in pharmacokinetic modeling

Application of SHAP values for inferring the optimal functional form of covariates in pharmacokinetic modeling

Abstract In population pharmacokinetic (PK) models, interindividual variability is explained by implementation of covariates in the model. The widely used forward stepwise selection method is sensitive to bias, which may lead to an incorrect inclusion of covariates. Alternatives, such as the full fi...

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Main Authors: Alexander Janssen (Author), Mark Hoogendoorn (Author), Marjon H. Cnossen (Author), Ron A. A. Mathôt (Author), the OPTI‐CLOT Study Group and SYMPHONY Consortium (Author)
Format: Book
Published: Wiley, 2022-08-01T00:00:00Z.
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