Drug Repurposing Using Molecular Network Analysis Identifies Jak as Targetable Driver in Necrobiosis Lipoidica

• Main Authors: Alysia N. Hughes (Author), Xing Li (Author), Julia S. Lehman (Author), Steven A. Nelson (Author), David J. DiCaudo (Author), Rekha Mudappathi (Author), Angelina Hwang (Author), Jacob Kechter (Author), Mark R. Pittelkow (Author), Aaron R. Mangold (Author), Aleksandar Sekulic (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug repurposing is an attractive strategy for therapy development, particularly in rare diseases where traditional drug development approaches may be challenging owing to high cost and small numbers of patients. In this study, we used a drug identification and repurposing pipeline to identify candi...