IL-6/JAK2-dependent G6PD phosphorylation promotes nucleotide synthesis and supports tumor growth

• Main Authors: Xuemei Qiu (Author), Hongping Ye (Author), Xiaofei Li (Author), Dan Li (Author), Lu Jiang (Author), Rui Liu (Author), Zhe Zhao (Author), Dan He (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Tumor cells hijack inflammatory mechanisms to promote their own growth. IL-6 is one of the major cytokines, and is frequently upregulated in tumors. The pentose phosphate pathway (PPP) generates the indispensable building blocks to produce various nucleotides. Here we aimed to determine w...