Pharmacokinetic assessment of pyrazinamide and pyrazinoic acid in carbon tetrachloride-induced liver injury model in Wistar Rats

• Main Authors: Swati Sharma (Author), Vishal Sharma (Author), Sunil Taneja (Author), Alka Bhatia (Author), Aishwarya Anand (Author), Dibyajyoti Banerjee (Author), Amol N Patil (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: We investigated the pharmacokinetic behavior of pyrazinamide (PZA) and pyrazinoic acid (PA) in the presence of carbon-tetrachloride (CCl4) plus antitubercular treatment (ATT) drug-induced liver injury (DILI) in rats. Methods: Thirty rats utilized in the experiment were separated equally...