The rLVS ΔcapB/iglABC vaccine provides potent protection in Fischer rats against inhalational tularemia caused by various virulent Francisella tularensis strains

• Main Authors: Kevin D. Mlynek (Author), Curtis R. Cline (Author), Sergei S. Biryukov (Author), Ronald G. Toothman (Author), Beth A. Bachert (Author), Christopher P. Klimko (Author), Jennifer L. Shoe (Author), Melissa Hunter (Author), Zander M. Hedrick (Author), Jennifer L. Dankmeyer (Author), Sherry Mou (Author), David P. Fetterer (Author), Ju Qiu (Author), Eric D. Lee (Author), Christopher K. Cote (Author), Qingmei Jia (Author), Marcus A. Horwitz (Author), Joel A. Bozue (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTFrancisella tularensis is one of the several biothreat agents for which a licensed vaccine is needed. To ensure vaccine protection is achieved across a range of virulent F. tularensis strains, we assembled and characterized a panel of F. tularensis isolates to be utilized as challenge strain...