Site-Specific Modification Using the 2'-Methoxyethyl Group Improves the Specificity and Activity of siRNAs
Rapid progress has been made toward small interfering RNA (siRNA)-based therapy for human disorders, but rationally optimizing siRNAs for high specificity and potent silencing remains a challenge. In this study, we explored the effect of chemical modification at the cleavage site of siRNAs. We found...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2017-12-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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Internet
Connect to this object online.3rd Floor Main Library
| Call Number: |
A1234.567 |
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| Copy 1 | Available |