Development of the First ¹⁸F-Labeled Radiohybrid-Based Minigastrin Derivative with High Target Affinity and Tumor Accumulation by Substitution of the Chelating Moiety

• मुख्य लेखकों: Thomas Günther (लेखक), Nadine Holzleitner (लेखक), Daniel Di Carlo (लेखक), Nicole Urtz-Urban (लेखक), Constantin Lapa (लेखक), Hans-Jürgen Wester (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

In order to optimize elevated kidney retention of previously reported minigastrin derivatives, we substituted (<i>R</i>)-DOTAGA by DOTA in (<i>R</i>)-DOTAGA-rhCCK-16/-18. CCK-2R-mediated internalization and affinity of the new compounds were determined using AR42J cells. Biod...