Development of the First ¹⁸F-Labeled Radiohybrid-Based Minigastrin Derivative with High Target Affinity and Tumor Accumulation by Substitution of the Chelating Moiety

• Κύριοι συγγραφείς: Thomas Günther (Συγγραφέας), Nadine Holzleitner (Συγγραφέας), Daniel Di Carlo (Συγγραφέας), Nicole Urtz-Urban (Συγγραφέας), Constantin Lapa (Συγγραφέας), Hans-Jürgen Wester (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2023-03-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

In order to optimize elevated kidney retention of previously reported minigastrin derivatives, we substituted (<i>R</i>)-DOTAGA by DOTA in (<i>R</i>)-DOTAGA-rhCCK-16/-18. CCK-2R-mediated internalization and affinity of the new compounds were determined using AR42J cells. Biod...