Development of the First ¹⁸F-Labeled Radiohybrid-Based Minigastrin Derivative with High Target Affinity and Tumor Accumulation by Substitution of the Chelating Moiety

• Váldodahkkit: Thomas Günther (Dahkki), Nadine Holzleitner (Dahkki), Daniel Di Carlo (Dahkki), Nicole Urtz-Urban (Dahkki), Constantin Lapa (Dahkki), Hans-Jürgen Wester (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2023-03-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

In order to optimize elevated kidney retention of previously reported minigastrin derivatives, we substituted (<i>R</i>)-DOTAGA by DOTA in (<i>R</i>)-DOTAGA-rhCCK-16/-18. CCK-2R-mediated internalization and affinity of the new compounds were determined using AR42J cells. Biod...