The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body.

• Auteurs principaux: Christal A Worthen (Auteur), Caroline A Enns (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2014-03-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Fine tuning of body iron is required to prevent diseases such as iron-overload and anemia. The putative iron-sensor, transferrin receptor 2 (TfR2), is expressed in the liver and mutations in this protein result in the iron-overload disease Type III hereditary hemochromatosis (HH). With the loss of f...