Design, synthesis and antitumor activity of 3,4,5-Trisubstituted Isoxazoles

Design, synthesis and antitumor activity of 3,4,5-Trisubstituted Isoxazoles

In this study, 56 isoxazole derivatives were synthesized and their antitumor activity against 9 cancer cells, such as BXPC-3, MiaPaCa-2, PANC-1, MCF-7, HCT-116, HepG2, NCI-H460, A549 and B16 was detected. The results of pharmacological experiments indicated that most compounds exhibit good cytotoxic...

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Main Authors: Kanghui Duan (Author), Fuxing Tan (Author), Hongming Xie (Author), Haiwang Liu (Author), Yingjun Zhang (Author), Huanfeng Jiang (Author), Wanqing Wu (Author)
Format: Book
Published: Elsevier, 2024-12-01T00:00:00Z.
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