Bivalent oral cholera vaccination induces a memory B cell response to the V. cholerae O1-polysaccharide antigen in Haitian adults.

• Main Authors: Brie Falkard (Author), Richelle C Charles (Author), Wilfredo R Matias (Author), Leslie M Mayo-Smith (Author), J Gregory Jerome (Author), Evan S Offord (Author), Peng Xu (Author), Pavol Kováč (Author), Edward T Ryan (Author), Firdausi Qadri (Author), Molly F Franke (Author), Louise C Ivers (Author), Jason B Harris (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The bivalent killed whole-cell oral cholera vaccine (BivWC) is being increasingly used to prevent cholera. The presence of O-antigen-specific memory B cells (MBC) has been associated with protective immunity against cholera, yet MBC responses have not been evaluated after BivWC vaccination. To addre...