The first activation study of a δ-carbonic anhydrase: TweCAδ from the diatom Thalassiosira weissflogii is effectively activated by amines and amino acids

• Main Authors: Andrea Angeli (Author), Fatmah A. S. Alasmary (Author), Sonia Del Prete (Author), Sameh M. Osman (Author), Zeid AlOthman (Author), William A. Donald (Author), Clemente Capasso (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The activation of the δ-class carbonic anhydrase (CAs, EC 4.2.1.1) from the diatom Thalassiosira weissflogii (TweCAδ) was investigated using a panel of natural and non-natural amino acids and amines. The most effective activator of TweCAδ was d-Tyr (KA of 51 nM), whereas several other amino acids an...